Rummy can be played with 2-player, 3-player, or 4-players. This is adjustable in the Settings menu.
The rules of the game are identical regardless of the number of players. The key differences are:
Winning Score. The default values are 100 points for a 2-player game, 200 points for a 3-player game, and 300 points for a 4-player game. However, this can be adjusted in Settings after you select your preferred number of players.
Hand Size. When playing with 1 deck, each player starts with 10 cards in a 2-player game and 7 cards for 3- and 4-player games. When playing with 2 decks, players start with 10 cards regardless of the number of players